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Cannabinoid CB2 Receptors in Brain Reward Systems

It is well known that the brain and body contain receptors that bind to tetrahydro-cannabinol (THC) the active ingredient in marijuana and that the body naturally produces substances known as cannabinoids that bind to these receptors. There are two known cannabinoid receptors, CB1 is located on neurons in the brain and spinal cord, and CB2 is located primarily on immune cells. Prior to the present study, it was unknown whether CB2 receptors could be found on neurons in the brain and what role they might play in brain function.

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